Cytokeratin 18
背景描述Description：
细胞角蛋白18(Cytokeratin 18，CK18)存在于单层上皮细胞、腺上皮细胞和移行上皮细胞中，而在复层上皮细胞中不表达。CK18通常与细胞角蛋白8(Cytokeratin 8)结合，抗细胞角蛋白18(Anti-Cytokeratin 18)可用于检测单纯和腺上皮源性腺癌以及低分化鳞癌细胞。
Cytokeratin 18 (CK18) is present in simple, glandular, and transitional epithelial cells, but is absent in stratified epithelial cells. CK18 usually multimerizes with Cytokeratin 8, and Anti-Cytokeratin 18 is useful for detecting adenocarcinomas of simple and glandular epithelium origin, as well as poorly differentiated squamous carcinoma cells.

Specifications
Clone IHC018
Source Mouse Monoclonal
Positive Control Breast, Breast Carcinoma
Dilution Range 1:50-1:200

参考文献References:
Moll R. Subcell Biochem. 1998; 31:205-62.
Ku NO, et al. J Clin Invest. 1997; 99:19-23.
Woelfle U, et al. Clin Cancer Res. 2004; 10:2670-4.