adam-ts7 peptide
2019-07-31
产品详情
- 产地 美国
- 产品名称adam-ts7 peptide
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- 简介
A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAM-TS7) is a metalloprotease that degrades COMP. ADAM-TS7 is up-regulated in articular cartilage and synovium from arthritis patients. The spacer domain and the thrombospondin type-1 domain are important for a tight interaction with the extracellular matrix. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.The synthetic peptide used to raise the antibody Cat. No. 250456 is selected from a sequence within the N-term region of human ADAM-TS7. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
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