er-alpha/beta peptide
2019-07-31
产品详情
- 产地 美国
- 产品名称er-alpha/beta peptide
查看相似产品 >
- 简介
Estrogen and progesterone receptors are members of a family transcription factors regulated by the binding of their cognate ligands. The interaction of hormone bound estrogen receptors with estrogen responsive elements (EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrogen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. Both have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B) which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A functions as a transcriptional inhibitor of all steroid hormone receptors.The synthetic peptide used to raise the antibody Cat. No. 250638 is selected from a sequence within the center region of human ER-alpha/beta. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
...
联系我们
推荐产品
产品展厅
