plp [139-151] peptide
2019-07-31
产品详情
- 产地 美国
- 产品名称plp [139-151] peptide
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- 简介
The PLP [139-151] peptide from the myelin proteolipid protein (PLP) has been found to be highly immunogenic in inducing experimental allergic encephalomyelitis (EAE) in SJC/J (H-2s) mice as part of an autoimmune response. The sequence is derived from PLP with a cysteine residue replaced by a serine. The peptide is conserved in mouse, rat, monkey, dog, pig, bovine and found to be similar in chicken, frog, turtle except for the first two residues. Mouse T-cell clones that are reactive with the peptide have been developped, and variations on the different clones' ability to elicit the immune response have been used to understand mechanisms of T-cell function. Later work has devised analogs of this peptide that block the immune response in vitro and in vivo, with implications for the regulation of autoimmune diseases.Human: H-His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe-OH or H-HSLGKWLGHPDKF-OH
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