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[arg3,14] ctx iv [3-14] peptide
2019-07-31
产品详情
- 产地 美国
- 产品名称[arg3,14] ctx iv [3-14] peptide
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- 简介
[Arg3,14] CTX IV [3-14] Peptide sequence corresponds to aa3-14 of the Cytotoxin IV (CTX IV), a toxin expressed by the venom gland of the Egyptian cobra. CTX IV has cytolytic activity on many different cells by forming pore in lipid membrane. CTX IV is a monomer in solution and forms homodimer and oligomer in the presence of negatively charged lipids forming a pore with a size ranging between 20 and 30 A. The toxin increases heart rate and kills the animal by cardiac arrest. The LD50 is 4.0 mg/kg by intravenous injection. CTX IV also binds to heparin with high affinity, interacts with Kv channel-interacting protein 1 (KCNIP1) in a calcium-independant manner, and binds to integrin alpha-V/beta-3 with moderate affinity.H-Arg-Asn-Arg-Leu-Ile-Pro-Pro-Phe-Trp-Lys-Thr-Arg-NH2 or H-RNRLIPPFWKTR-NH2
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