产品展厅
perk peptide
2019-07-31
产品详情
- 产地 美国
- 产品名称perk peptide
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- 简介
PERK, a Ser/Thr protein kinase, phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and to a rapid reduction of translational initiation and repression of global protein synthesis. PERK serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1. Defects in PERK are the cause of Wolcott-Rallison syndrome, an early-onset diabetes mellitus.The synthetic peptide used to raise the antibody Cat. No. 200117 is selected from a sequence within the C-term region of human PERK. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
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