产品背景Description 

The CD45 antigen (Receptor-type tyrosine-protein phosphatase C, PTPRC) is a protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. CD45 acts as a positive regulator of T-cell coactivation upon binding to DPP4. Defects in CD45 are a cause of severe combined immunodefiency autosomal recessive T-cell negative/B-cell-positive/NK-cell-positive (T-B+NK+ SCID). Genetic variations in CD45 are involved in multiple sclerosis susceptibility.

别名Alternate Names 

Leukocyte common antigen; L-CA; T200; CD45 antigen; PTPRC; Receptor-type tyrosine-protein phosphatase C; CD45

应用说明Application Notes 

E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

引用文献Product Citations 

[1] Karaca T et al. 2015. Iran J Basic Med Sci. 18(4): 370-379. PMID 26019800. [2] Karaca T et al. 2011. Allergologia Immunopathologia. 40(6): 357-361. PMID 22115572.