产品背景

KISS1 (Metastasis-suppressor KiSS-1) is a metastasis suppressor protein found in malignant melanomas and in some breast cancers. KISS1 regulates events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. KISS1 generates a C-terminally amidated peptide, metastin, which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of this receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca2+ levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty.

别名Alternate Names 

Metastasis-suppressor KiSS-1; Kisspeptin-1; KiSS-1; Metastin; Kisspeptin-14; Kisspeptin-13; Kisspeptin-10; KISS1

应用说明Application Notes 

E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

引用文献Product Citations 

[1] Luo QQ et al. 2016. J Chin Med Assoc. 79(10): 546-53. PMID 27373140. [2] Luo Q et al. 2016. Life Sci. 153: 207-12. PMID 27212704. [3] Zhou Q et al. 2014. Reprod Biol Endocrinol. 12: 127. PMID 25542298.