产品背景Description 

YAP (Yes-associated protein) is a transcription coactivator in the Hippo tumor suppressor pathway and controls cell growth, tissue homeostasis and in organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteosomal degradation. YAP induces gene expression by binding to the TEAD family transcription factors. Dysregulation of the Hippo-YAP pathway is frequently observed in human cancers. AMPK directly phosphorylates YAP at Ser94, a residue essential for the interaction with TEAD, thus disrupting the YAP-TEAD interaction.

别名Alternate Names 

Yorkie homolog; 65 kDa Yes-associated protein; YAP65; YAP1; Transcriptional coactivator YAP1; Yes-associated protein 1; Yes associated protein YAP65 homolog

应用说明Application Notes 

YAP1 (Ser94) Antibody recognizes endogenous and transfected levels of YAP1 when phosphorylated at Ser94 (Ser79 in mouse and rat). E: 1:5,000-1:20,000; WB: 1:1,000-1:10,000

引用文献Product Citations 

Mo J-S. et al. 2015. Nature Cell Biology. 17(3): 500-10. PMID# 25751140.