产品背景Description 

The organic anion transporter 1 (OAT-1 or SLC22A6) is localized to the basolateral membrane of renal tubular epithelial cells and plays a critical role in the excretion and detoxification of anionic compounds. OAT-1 functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). OAT-1 mediates the sodium-independant uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS), p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV) and many other organic compounds.

别名Alternate Names 

Solute carrier family 22 member 6; Organic anion transporter 1; OAT1; Renal organic anion transporter 1; ROAT1; Novel kidney transcript; NKT; SLC22A6

应用说明Application Notes 

E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

引用文献Product Citations 

[1] Naud J et al. 2011. Drug Metabolism and Disposition. 39(8):1363-1369. PMID# 21525170. [2] Eisner C et al. 2012. Kidney International. 77:519-526. PMID# 20032962.